Version: 8.0.0
Date: Tue Jan 28 2025
sbp-1
Caenorhabditis elegansWB:WBGene00004735
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sbp-1

Species
Caenorhabditis elegans
Symbol
sbp-1
Name
Sterol regulatory element Binding Protein 1
Synonyms
  • CELE_Y47D3B.7
  • hlh-20
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity. Involved in several processes, including cellular response to zinc ion; fatty acid metabolic process; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Is expressed in several structures, including head; intestine; and terminal bulb. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to several human genes including SREBF2 (sterol regulatory element binding transcription factor 2).
WB Description
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; in addition, sbp-1 is required for mediating the lipid accumulation and increased body width/length ratio that occurs in response to oxygen deprivation; sbp-1 expression is detected in the intestine, the major site of fat storage, from early embryogenesis through adulthood and also in the amphid neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46062
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          sbp-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            sbp-1 role
            sbp-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
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