Version: 8.0.0Date: Tue Jan 28 2025
Gene
sdn-1
- Species
- Caenorhabditis elegans
- Symbol
- sdn-1
- Name
- SynDecaN 1
- Synonyms
- CELE_F57C7.3
- F57C7.3
- Biotype
- protein coding gene
- Automated Description
- Involved in embryo development; epidermis morphogenesis; and nematode larval development. Located in cell surface. Is expressed in several structures, including ABar; C; neuroblasts; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in cleft lip and cleft palate. Orthologous to human SDC1 (syndecan 1); SDC2 (syndecan 2); and SDC4 (syndecan 4).
- WB Description
- sdn-1 encodes a homolog of vertebrate syndecan-2, a type I transmembrane heparan sulfate proteoglycan; by homology, SDN-1 is predicted to play a role in cell-cell and cell-matrix adhesion; loss of sdn-1 activity via RNA-mediated interference (RNAi) indicates that SDN-1 is required for backward locomotion and for normal development of the egg-laying system, particularly gonadal and vulval structures; SDN-1 is expressed in a subset of neuronal cell bodies and their associated processes in the nerve ring, and also in select tail neurons.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10915
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
Phenotype Term | Annotation details | References |
|---|---|---|
| No records match query. Try removing filters. | ||
Showing 0 - 0 of 0 rows
per page
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
Showing 0 - 0 of 0 rows
per page
Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
Showing 0 - 0 of 0 rows
per page
Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||
Showing 0 - 0 of 0 rows
per page
Sequence Feature Viewer
- Genome location
- ChrX:10589770...10593334 - (3.56 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.