Version: 8.1.0
Date: Fri Apr 18 2025
sem-4
Caenorhabditis elegansWB:WBGene00004773
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sem-4

Species
Caenorhabditis elegans
Symbol
sem-4
Name
SEx Muscle abnormal 4
Synonyms
  • CELE_F15C11.1
  • F15C11.1
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of transcription by RNA polymerase II; transdifferentiation; and vulval cell fate determination. Located in nucleus. Is expressed in several structures, including M lineage cell; nervous system; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane-radial ray syndrome; Holt-Oram syndrome; IVIC syndrome; Townes-Brocks syndrome; and coloboma. Orthologous to several human genes including SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3).
WB Description
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; sem-4 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; a SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23233
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          sem-4 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection method
          Source
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            Genetic Interactions

            sem-4 role
            sem-4 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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