Version: 8.0.0
Date: Tue Jan 28 2025
slo-2
Caenorhabditis elegansWB:WBGene00004831
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

slo-2

Species
Caenorhabditis elegans
Symbol
slo-2
Name
SLOwpoke potassium channel family 2
Synonyms
  • CELE_F08B12.3
  • F08B12.3
Biotype
protein coding gene
Automated Description
Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Is expressed in body wall musculature; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2).
WB Description
slo-2 encodes a high conductance, sodium-activated potassium channel; when expressed in Xenopus oocytes, SLO-2 exhibits a synergistic dependence on both chloride and calcium ions for activation; expression of a dominant negative SLO-2 mutant can interfere with activity of SLO-1, a second high conductance potassium channel, suggesting that the two channels can form functional heteromultimers; a SLO-2::GFP fusion protein is expressed in body wall, vulval, and pharyngeal/intestinal valve muscles, nerve ring processes, and some motor neurons in the ventral nerve cord; SLO-2 expression largely overlaps with that of SLO-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10027
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            11.396M11.398M11.400M11.402M11.404M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            slo-2 molecule type
            Interactor gene
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              Genetic Interactions

              slo-2 role
              slo-2 genetic perturbation
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