Gene

slt-1

Species
Caenorhabditis elegans
Symbol
slt-1
Name
SLiT (Drosophila) homolog 1
Synonyms
  • CELE_F40E10.4
  • F40E10.4
Biotype
protein coding gene
Automated Description
Enables signaling receptor binding activity. Involved in axon guidance; neuron migration; and regulation of neuron projection development. Predicted to be located in extracellular region. Is expressed in anal sphincter muscle; anterior hypodermis; body wall musculature; nerve ring neurons; and socket cell. Orthologous to human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3).
WB Description
slt-1 encodes the sole C. elegans homolog of Drosophila Split, a secreted extracellular protein containing leucine-rich and EGF-like repeats that functions as a ligand for the Robo receptor; during C. elegans larval development, slt-1 acts via the SAX-3/Robo receptor, and in parallel with UNC-6/Netrin, to direct ventral axon guidance and guidance at the midline; during embryonic development, slt-1 also functions to regulate anterior-posterior migrations of the CAN neurons; slt-1::gfp reporters are initially expressed at high levels in the anterior part of the embryo, with more moderate levels seen in dorsal tail muscles and lower levels seen in cells in the center of the body; in L1 larvae, slt-1::gfp is expressed in both dorsal and ventral muscles, with higher levels seen in dorsal muscle cells; slt-1::gfp is also expressed in a number of additional cells including some neurons, pharyngeal cells, and the anal sphincter muscle.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45836
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            14.675M14.676M14.677M14.678M14.679M14.680M14.681M14.682M14.683M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            slt-1 molecule type
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              Genetic Interactions

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