Gene

sms-1

Species
Caenorhabditis elegans
Symbol
sms-1
Name
SphingoMyelin Synthase 1
Synonyms
  • CELE_H21P03.3
  • H21P03.3
Biotype
protein coding gene
Automated Description
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including body wall musculature; pharyngeal cell; rectal muscle; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Orthologous to several human genes including SGMS2 (sphingomyelin synthase 2).
WB Description
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Expressed in head muscle; pharyngeal cell; rectal muscle; spermatheca; and vulval muscle. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Is an ortholog of human SGMS2 (sphingomyelin synthase 2).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21290
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
sms-3143342273 of 8  
F53B1.2239444284 of 8  
sms-2325655363 of 8  
sms-5424953343 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.484M11.486M11.488M11.490M11.492M11.494M11.496M11.498M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions