Gene

sol-1

Species
Caenorhabditis elegans
Symbol
sol-1
Name
Suppressor Of Lurcher movement defect 1
Synonyms
  • C15A11.3
  • CELE_C15A11.3
Biotype
protein coding gene
Automated Description
Enables channel regulator activity. Involved in several processes, including hyperosmotic response; positive regulation of glutamatergic synaptic transmission; and thigmotaxis. Located in neuron projection membrane and synapse. Part of ionotropic glutamate receptor complex.
WB Description
sol-1 encodes a CUB domain-containing type I transmembrane protein; SOL-1 functions as an auxiliary protein for the AMPA-subtype ionotropic glutamate receptor GLR-1; specifically, SOL-1 regulates GLR-1's rate of desensitization as well as rate of recovery from desensitization; a secreted form of SOL-1 is sufficient to rescue behavioral and synaptic signaling defects of sol-1 mutant animals.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47537
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.390M7.391M7.392M7.393M7.394M7.395M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sol-1 molecule type
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              Genetic Interactions

              sol-1 role
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