Gene

spe-9

Species
Caenorhabditis elegans
Symbol
spe-9
Name
defective SPErmatogenesis 9
Synonyms
  • C17D12.6
  • CELE_C17D12.6
Biotype
protein coding gene
Automated Description
Predicted to enable signaling receptor binding activity. Involved in single fertilization. Located in cell surface; cytoplasm; and pseudopodium. Is expressed in sperm and spermatid. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4).
WB Description
spe-9 encodes an EGF repeat-containing protein with a short intracellular domain; SPE-9 is required autonomously in sperm for fertilization, and by homology, likely mediates an adhesive or signaling event necessary for proper oocyte fertilization; spe-9 mRNA is detected solely in animals that are engaged in spermatogenesis; in spermatids, SPE-9 is found at or near the cell surface; following sperm activation, SPE-9 is found primarily on the pseudopod.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24033
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.5830M11.5835M11.5840M11.5845M11.5850M11.5855M11.5860M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions