Version: 8.0.0
Date: Tue Jan 28 2025
spp-10
Caenorhabditis elegansWB:WBGene00004995
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

spp-10

Species
Caenorhabditis elegans
Symbol
spp-10
Name
SaPosin-like Protein family 10
Synonyms
  • C28C12.7
  • CELE_C28C12.7
Biotype
protein coding gene
Automated Description
Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Predicted to be active in extracellular space. Is expressed in body wall musculature; intestine; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; lung disease (multiple); respiratory syncytial virus infectious disease; sphingolipidosis (multiple); and toxic shock syndrome. Orthologous to several human genes including PSAP (prosaposin) and PSAPL1 (prosaposin like 1).
WB Description
spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11480
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            8.4775M8.4780M8.4785M8.4790M8.4795M8.4800M8.4805M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            spp-10 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              spp-10 role
              spp-10 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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