Gene

jmjd-1.1

Species
Caenorhabditis elegans
Symbol
jmjd-1.1
Name
JuMonJi (transcription factor) Domain protein 1.1
Synonyms
  • CELE_F43G6.6
  • F43G6.6
Biotype
protein coding gene
Automated Description
Predicted to enable histone demethylase activity and transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in melanoma and syndromic X-linked intellectual disability Siderius type. Orthologous to several human genes including KDM7A (lysine demethylase 7A).
WB Description
jmjd-1.1 encodes a PHD and JmjC domain-containing protein that is a member of a family of proteins containing members, such as jmjd-1.2 and human PHF8, with histone demethylase activity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23123
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensKDM7A6 of 9YesYes   
Homo sapiensPHF25 of 9NoYes   
Homo sapiensPHF85 of 9NoYes   
Mus musculusKdm7a5 of 9YesYes   
Rattus norvegicusPhf86 of 9YesNo   
Rattus norvegicusPhf8l5 of 9NoYes   
Xenopus tropicaliskdm7a5 of 9YesYes   
Danio reriokdm7ab5 of 9YesYes   
Danio reriophf85 of 9YesNo   
Danio reriophf25 of 9YesYes   
Danio reriokdm7aa5 of 9YesYes   
Saccharomyces cerevisiaeJHD14 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
jmjd-1.2157475607 of 8  
jhdm-1247246285 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
high susceptibility to induced DNA damage
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
11.8066M11.8068M11.8070M11.8072M11.8074M11.8076M11.8078M11.8080M11.8082M11.8084M11.8086M11.8088M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
hc184allele
tm3980allele with one associated variant
deletion
  • splice acceptor variant
Yes
NC_003280.10:g.11808087C>Tvariant
SNP
  • missense variant
NC_003280.10:g.11807958T>Cvariant
SNP
  • missense variant
NC_003280.10:g.11808431A>Tvariant
SNP
  • missense variant
NC_003280.10:g.11808106C>Tvariant
SNP
  • synonymous variant
NC_003280.10:g.11807972C>Avariant
SNP
  • missense variant
NC_003280.10:g.11808222A>Tvariant
SNP
  • missense variant
NC_003280.10:g.11808358C>Tvariant
SNP
  • missense variant
NC_003280.10:g.11808890C>Tvariant
SNP
  • 3 prime UTR variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
BA1083WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.8066M11.8068M11.8070M11.8072M11.8074M11.8076M11.8078M11.8080M11.8082M11.8084M11.8086M11.8088MF43G6.6.1 (jmjd-1.1)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 2 annotations
jmjd-1.1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
tbx-9Caenorhabditis elegans
protein
  • two hybrid
PMID:23791784
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Genetic Interactions

jmjd-1.1 role
jmjd-1.1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
hypostatic gene
hc184spr-5Caenorhabditis elegans
epistatic gene
by101
genetic epistasis (sensu Bateson)
    PMID:24685137
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