Gene

sqv-7

Species
Caenorhabditis elegans
Symbol
sqv-7
Name
SQuashed Vulva 7
Synonyms
  • C52E12.3
  • CELE_C52E12.3
Biotype
protein coding gene
Automated Description
Enables UDP-N-acetylgalactosamine transmembrane transporter activity; UDP-galactose transmembrane transporter activity; and UDP-glucuronic acid transmembrane transporter activity. Involved in several processes, including egg-laying behavior; proteoglycan biosynthetic process; and pyrimidine nucleotide-sugar transmembrane transport. Located in cytoplasm. Is expressed in several structures, including hermaphrodite distal tip cell; intestine; nervous system; oocyte; and vulval cell. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Orthologous to several human genes including SLC35D1 (solute carrier family 35 member D1).
WB Description
The sqv-7 gene encodes a nucleotide-sugar transporter of the Golgi membrane, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-7 promotes glycosaminoglycan biosynthesis by translocating UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose into the lumen of the Golgi apparatus; SQV-7 is biochemically active when transgenically expressed in yeast or mammalian Golgi membranes; the common requirement for SQV-7 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11132
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.0108M7.0110M7.0112M7.0114M7.0116M7.0118M7.0120M7.0122M7.0124M7.0126M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sqv-7 molecule type
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              Genetic Interactions

              sqv-7 role
              sqv-7 genetic perturbation
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