Enables glucuronosyltransferase activity. Involved in several processes, including chondroitin sulfate biosynthetic process; egg-laying behavior; and vulval development. Located in membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3).
WB Description
The sqv-8 gene encodes a glucuronyl transferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-8 is homologous to three distinct glucuronyl transferases (GlcAT-I, GlcAT-P and GlcAT-D) that play a role in the synthesis of different glycoconjugates; the common requirement for SQV-8 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.