Gene

sqv-8

Species
Caenorhabditis elegans
Symbol
sqv-8
Name
SQuashed Vulva 8
Synonyms
  • CELE_ZK1307.5
  • spe-2
Biotype
protein coding gene
Automated Description
Enables glucuronosyltransferase activity. Involved in several processes, including chondroitin sulfate biosynthetic process; egg-laying behavior; and vulval development. Located in membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3).
WB Description
The sqv-8 gene encodes a glucuronyl transferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-8 is homologous to three distinct glucuronyl transferases (GlcAT-I, GlcAT-P and GlcAT-D) that play a role in the synthesis of different glycoconjugates; the common requirement for SQV-8 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10896
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.6470M9.6472M9.6474M9.6476M9.6478M9.6480M9.6482M9.6484M9.6486M9.6488M9.6490M9.6492M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions