Gene

stn-1

Species
Caenorhabditis elegans
Symbol
stn-1
Name
SynTrophiN 1
Synonyms
  • CELE_F30A10.8
  • F30A10.8
Biotype
protein coding gene
Automated Description
Enables acetylcholine transmembrane transporter activity and calcium channel regulator activity. Involved in several processes, including acetylcholine transport; muscle cell cellular homeostasis; and sarcomere organization. Part of dystrophin-associated glycoprotein complex. Is expressed in body wall musculature; enteric muscle; nervous system; and reproductive system. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 12; and sudden infant death syndrome. Orthologous to several human genes including SNTB2 (syntrophin beta 2).
WB Description
stn-1 encodes a syntrophin, a PDZ and PH domain-containing adaptor protein, with homology to vertebrate alpha and beta-syntrophins; stn-1 activity is required in muscles for normal locomotory behavior: in the absence of stn-1, animals are hyperactive, display exaggerated head movement when moving forward, and hypercontract upon backward locomotion; stn-1 is likely to function in the same pathway as dys-1/dystrophin, as single and double mutants have the same phenotype and STN-1 physically interacts with DYB-1/dystrobrevin; STN-1 also physically interacts with the SNF-6 acetylcholine transporter, and the novel ISLO-1 adaptor protein; stn-1 is expressed beginning at the two-fold stage of embryogenesis and is seen in muscles, including body wall, vulval, and head muscles, and neurons, including head neurons and the ventral nerve cord.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10554
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.5015M9.5020M9.5025M9.5030M9.5035M9.5040M9.5045M9.5050M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            stn-1 molecule type
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              Genetic Interactions

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