Gene

syg-1

Species
Caenorhabditis elegans
Symbol
syg-1
Name
SYnaptoGenesis abnormal 1
Synonyms
  • CELE_K02E10.8
  • K02E10.8
Biotype
protein coding gene
Automated Description
Enables cell adhesion molecule binding activity. Involved in actin filament bundle assembly; cell-cell signaling; and nervous system development. Located in axon and synapse. Is expressed in amphid sheath cell; egg-laying apparatus; head muscle; and neurons. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to several human genes including KIRREL1 (kirre like nephrin family adhesion molecule 1) and KIRREL2 (kirre like nephrin family adhesion molecule 2).
WB Description
syg-1 encodes a novel transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-1 activity is required cell autonomously within the HSNL neuron to specify proper synaptic specificity with its targets, such as vulval muscles and the VC neuron; in regulating synapse formation, SYG-1 acts as a receptor for a second immunoglobulin superfamily protein, SYG-2, a synaptic guidepost protein that interacts with SYG-1 and whose activity is essential for proper SYG-1 localization in HSNL; expression of a SYG-1::GFP reporter fusion in HSNL under the control of the unc-86 promoter reveals that SYG-1 localizes to axons and accumulates at future sites of synaptic vesicle clustering, while expression under an endogenous reporter reveals weak expression in head motorneurons, occasionally in HSN neurons, and in other cells in the vulval region.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11640
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            2.510M2.511M2.512M2.513M2.514M2.515M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            syg-1 molecule type
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              Genetic Interactions

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