Gene

pak-2

Species
Caenorhabditis elegans
Symbol
pak-2
Name
P21-Activated Kinase family 2
Synonyms
  • C45B11.1
  • CELE_C45B11.1
Biotype
protein coding gene
Automated Description
Predicted to enable protein serine/threonine kinase activity. Involved in nematode larval development. Predicted to be active in cytoplasm. Is expressed in hypodermis; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK4 (p21 (RAC1) activated kinase 4).
WB Description
pak-2 encodes, by alternative splicing, at least two isoforms of aputative p21-activated kinase, orthologous to Drosophila melanogasterMUSHROOM BODIES TINY; pak-2 is expressed in pharynx, thepharyngeal-intestinal valve, vulva, and spermatheca; pak-2(ok332), aprobable null allele, has no obvious mutant phenotype in isolation andhas no effect on the axonal guidance phenotype of max-2(cy2), but showssome embryonic defects and L1 lethality as a double mutant with the nullpak-1(ok448).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48015
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.0365M11.0370M11.0375M11.0380M11.0385M11.0390M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions