Predicted to enable protein serine/threonine kinase activity. Involved in nematode larval development. Predicted to be active in cytoplasm. Is expressed in hypodermis; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK4 (p21 (RAC1) activated kinase 4).
WB Description
pak-2 encodes, by alternative splicing, at least two isoforms of aputative p21-activated kinase, orthologous to Drosophila melanogasterMUSHROOM BODIES TINY; pak-2 is expressed in pharynx, thepharyngeal-intestinal valve, vulva, and spermatheca; pak-2(ok332), aprobable null allele, has no obvious mutant phenotype in isolation andhas no effect on the axonal guidance phenotype of max-2(cy2), but showssome embryonic defects and L1 lethality as a double mutant with the nullpak-1(ok448).