Gene

fntb-1

Species
Caenorhabditis elegans
Symbol
fntb-1
Name
FarNesylTransferase, Beta subunit 1
Synonyms
  • CELE_F23B12.6
  • F23B12.6
Biotype
protein coding gene
Automated Description
Predicted to enable protein prenyltransferase activity and zinc ion binding activity. Predicted to contribute to protein farnesyltransferase activity. Predicted to be involved in prenylation. Predicted to be part of protein farnesyltransferase complex. Is expressed in body wall musculature; neurons; pharyngeal muscle cell; rectal epithelial cell; and vulval cell. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to human CHURC1-FNTB (CHURC1-FNTB readthrough) and FNTB (farnesyltransferase, CAAX box, subunit beta).
WB Description
Predicted to enable protein prenyltransferase activity and zinc ion binding activity. Predicted to contribute to protein farnesyltransferase activity. Predicted to be involved in prenylation. Predicted to be part of protein farnesyltransferase complex. Expressed in body wall musculature; neurons; pharyngeal muscle cell; rectal epithelial cell; and vulval cell. Human ortholog(s) of this gene implicated in anxiety disorder. Is an ortholog of human CHURC1-FNTB (CHURC1-FNTB readthrough) and FNTB (farnesyltransferase, CAAX box, subunit beta).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11774
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCHURC1-FNTB9 of 9YesYes   
Homo sapiensFNTB9 of 9YesYes   
Mus musculusFntb9 of 9YesYes   
Rattus norvegicusFntb9 of 9YesYes   
Xenopus tropicalisfntb5 of 9YesYes   
Danio reriofntb9 of 9YesYes   
Drosophila melanogasterFntb9 of 9YesYes   
Saccharomyces cerevisiaeRAM18 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
ggtb-1134448313 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
14.4478M14.4480M14.4482M14.4484M14.4486M14.4488M14.4490M14.4492M14.4494M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_003283.11:g.14449459C>Tvariant
SNP
  • 3 prime UTR variant
NC_003283.11:g.14447671T>Cvariant
SNP
  • 5 prime UTR variant
NC_003283.11:g.14447677G>Avariant
SNP
  • 5 prime UTR variant
NC_003283.11:g.14447716T>Cvariant
NC_003283.11:g.14448472G>Avariant
NC_003283.11:g.14448789G>Avariant
SNP
  • synonymous variant
NC_003283.11:g.14449210C>Tvariant
SNP
  • missense variant
NC_003283.11:g.14448033C>Tvariant
SNP
  • synonymous variant
NC_003283.11:g.14448611A>Gvariant
SNP
  • splice region variant
NC_003283.11:g.14448954C>Tvariant
SNP
  • missense variant
Showing 1 - 10 of 35 rows
per page

Transgenic Alleles

No data available

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
14.4478M14.4480M14.4482M14.4484M14.4486M14.4488M14.4490M14.4492M14.4494MF23B12.6.1 (fntb-1)F23B12.6.2 (fntb-1)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

10 interactor genes based on 12 annotations
fntb-1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
act-5Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36261024
protein
arid-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:37818613
protein
elks-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34416233
protein
endu-2Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:37443152
protein
fnta-1Caenorhabditis elegans
protein
  • two hybrid
PMID:11731503
protein
fnta-1Caenorhabditis elegans
protein
  • two hybrid
PMID:19123269
protein
mbk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:26912668
protein
pid-5Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:33231880
protein
plk-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:35442950
protein
sao-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36323675
Showing 1 - 10 of 12 rows
per page

Genetic Interactions