Gene

rhgf-2

Species
Caenorhabditis elegans
Symbol
rhgf-2
Name
RHo Guanine nucleotide exchange Factor 2
Synonyms
  • CELE_T08H4.1
  • T08H4.1
Biotype
protein coding gene
Automated Description
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including Rho protein signal transduction; embryonic body morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in axon and cell body. Is expressed in nervous system; pharyngeal cell; seam cell; and tail. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to several human genes including PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).
WB Description
rhgf-2 encodes a Rho guanyl-nucleotide exchange factor (RhoGEF) with similarity to the mammalian PLEKHG5/Tech/Syx RhoGEFs; rhgf-2 is required for embryonic morphogenesis, larval development, and regulation of locomotion; when expressed in mammalian neuronal tissue culture cells, RHGF-2 induces cell rounding inhibits neurite outgrowth; RHGF-2 functions as a RhoGEF for the RHO-1 GTPase; RHGF-2 physically interacts with the multi-PDZ domain scaffold protein MPZ-1; RHGF-2 is expressed in many, but not all, C. elegans neurons from the 1.5-fold stage of embryogenesis through adulthood; in nerve ring axons, RHGF-2 expression overlaps with that of MPZ-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13217
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            4.105M4.110M4.115M4.120M4.125M

            Sequence Details

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            Expression

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            Molecular Interactions

            rhgf-2 molecule type
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              Genetic Interactions

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