Version: 8.0.0
Date: Tue Jan 28 2025
ten-1
Caenorhabditis elegansWB:WBGene00006498
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ten-1

Species
Caenorhabditis elegans
Symbol
ten-1
Name
TENeurin 1
Synonyms
  • CELE_R13F6.4
  • mnm-5
Biotype
protein coding gene
Automated Description
Involved in several processes, including axon development; basement membrane assembly involved in embryonic body morphogenesis; and gonad development. Located in nucleus and plasma membrane. Is expressed in several structures, including body muscle cell; epithelial cell; gonad; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in cocaine dependence and essential tremor 5. Orthologous to several human genes including TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3).
WB Description
ten-1 encodes a type II transmembrane protein containing EGF-like repeats that is the C. elegans ortholog of Drosophila Ten-m/Odz and vertebrate teneurins (OMIM:300588); in C. elegans, TEN-1 is required for proper development of the gonadal and pharyngeal basement membranes and for proper axonal placement and hypodermal morphogenesis; ten-1 and phy-1 act in parallel influencing the connection between epidermis and muscle during embryonic development; TEN-1 acts as an epidermal receptor for the BM collagens modified by PHY-1 and secreted by the muscle cells; loss of P4H function in ten-1 null mutants results in embryonic lethality due to arrest during late elongation with morphological defects; ten-1; phy-1 embryos have defects in epidermal development and body wall muscles due to basement membrane defects in arrested embryos; TEN-1 is expressed in the embryo and in multiple tissues during postembryonic development including the somatic gonad founder cells Z1 and Z4 and their descendants, as well as in six marginal cells and the M2 neurons in the pharynx; in the embryo, ten-1 expression overlaps with that of lat-1 in the dorsal left epidermoblasts; as ten-1 and lat-1 also display genetic interactions during embryonic development, the overlapping expression patterns suggest that these two genes have overlapping functions during embryogenesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11219
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            6.825M6.830M6.835M6.840M6.845M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ten-1 molecule type
            Interactor gene
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              Genetic Interactions

              ten-1 role
              ten-1 genetic perturbation
              Interactor gene
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              Interactor role
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