Gene

tdp-1

Species
Caenorhabditis elegans
Symbol
tdp-1
Name
TAR DNA-binding Protein homolog 1
Synonyms
  • CELE_F44G4.4
  • F44G4.4
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and single-stranded RNA binding activity. Involved in several processes, including RNA splicing; determination of adult lifespan; and hyperosmotic response. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; muscle cell; neurons; and pharynx. Used to study amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 10. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein).
WB Description
tdp-1 encodes the C. elegans ortholog of human TAR DNA/RNA binding protein TDP-43 (HGNC:TARDBP); in C. elegans TDP-1 is involved in the response to oxidative stress and age-dependent proteotoxicity; tdp-1 exhibits a dose-dependent effect on lifespan, and is required for the long lifespan and oxidative stress resistance of daf-2 mutants; based on homology to TDP-43, TDP-1 is predicted to have nucleic acid binding activity and function in RNA processing and metabolism; TDP-1 is widely expressed and in unstressed animals is found at low levels in the nucleus; in the presence of oxidative stress, however, TDP-1 levels increase.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48033
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.9980M8.9982M8.9984M8.9986M8.9988M8.9990M8.9992M8.9994M8.9996M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            tdp-1 molecule type
            Interactor gene
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              Genetic Interactions

              tdp-1 role
              tdp-1 genetic perturbation
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