Predicted to enable GTP binding activity and microtubule nucleator activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including detection of temperature stimulus; maintenance of centrosome location; and microtubule cytoskeleton organization. Located in centrosome and cytoplasm. Is expressed in gonad. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG2 (tubulin gamma 2).
WB Description
tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required fornormal bipolar spindle assembly and function, as well as the fast phase of female pronuclearmigration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.