Gene

tbg-1

Species
Caenorhabditis elegans
Symbol
tbg-1
Name
TuBulin, Gamma 1
Synonyms
  • CELE_F58A4.8
  • F58A4.8
Biotype
protein coding gene
Automated Description
Predicted to enable GTP binding activity and microtubule nucleator activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including detection of temperature stimulus; maintenance of centrosome location; and microtubule cytoskeleton organization. Located in centrosome and cytoplasm. Is expressed in gonad. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG2 (tubulin gamma 2).
WB Description
tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required fornormal bipolar spindle assembly and function, as well as the fast phase of female pronuclearmigration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11588
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.6270M9.6275M9.6280M9.6285M9.6290M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions