Version: 8.1.0
Date: Fri Apr 18 2025
tbx-2
Caenorhabditis elegansWB:WBGene00006543
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tbx-2

Species
Caenorhabditis elegans
Symbol
tbx-2
Name
T BoX family 2
Synonyms
  • CELE_F21H11.3
  • F21H11.3
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription repressor activity; core promoter sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including muscle cell fate specification; nematode pharyngeal muscle development; and olfactory behavior. Located in cytoplasm and nucleus. Is expressed in several structures, including amphid neurons; anal region; head; pharynx; and vulva. Human ortholog(s) of this gene implicated in atrial heart septal defect; heart septal defect; ulnar-mammary syndrome; and vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3).
WB Description
tbx-2 encodes one of 21 C. elegans T-box transcription factors; during development, tbx-2 activity is required for normal adaptation, but not chemotaxis, to attractive odorants sensed by the AWC amphid neurons; tbx-2 is required redundantly with unc-3 and unc-31 for negative regulation of dauer formation, and large-scale RNAi screens reveal an essential role for tbx-2 in early larval development, normal rates of postembryonic growth, and locomotory behavior; tbx-2 is also required along with pha-4 for embryonic precursor cells to adopt a pharyngeal muscle fate; TBX-2 and PHA-4 are mutually dependant on each other to maintain expression implicating them in a regulatory loop that controls commitment to the pharyngeal muscle fate; yeast two-hybrid assays have identified that TBX-2 interacts with UBC-9 (E2 SUMO conjugating enzyme) and GEI-17 (E3 SUMO ligase); based on the two-hybrid interaction and the similar pharyngeal muscle phenotype of ubc-9, it is likely that protein sumoylation is required for precursor-cell derived pharyngeal muscle development; antibodies to TBX-2 detect expression in the cytoplasm of amphid and pharyngeal neurons in larvae and adults, suggesting that TBX-2 function may be controlled, in part, by regulation of its subcellular localization; in addition, in situ hybridization studies indicate that tbx-2 mRNA is expressed during mid-embryogenesis; tbx-2 expression in the AWC amphid neurons is sufficient to rescue the olfactory adaptation defects seen in tbx-2 mutant animals.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11267
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

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      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

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          Assembly version
          WBcel235
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          Sequence Details

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          Expression

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          Molecular Interactions

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            Genetic Interactions

            tbx-2 role
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