Gene

tim-1

Species
Caenorhabditis elegans
Symbol
tim-1
Name
TIMeless (Drosophila/mammal) related 1
Synonyms
  • CELE_Y75B8A.22
  • csg-5
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity. Involved in embryo development; regulation of sister chromatid cohesion; and sister chromatid cohesion. Located in nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator).
WB Description
tim-1 encodes the C. elegans ortholog of mammalian timeless and Drosophila timeout proteins; in C. elegans, TIM-1 activity is essential for regulation of chromatid cohesion and thus, for proper meiotic and mitotic chromosome behavior and normal embryonic development; in addition, TIM-1 appears to also play a role in regulation of developmental timing, controlling the temporal identity of hypodermal seam cells during postembryonic development; during meiosis, TIM-1 activity is required for assembly of non-SMC members of the cohesin complex (REC-8 and SCC-3 in meiosis) onto chromosomes; immunoprecipitation experiments demonstrate that TIM-1 associates with mitotic cohesin subunits SMC-1, SMC-3, SCC-1, and SCC-3 in vivo, although TIM-1 is unlikely to be a core member of the cohesin complex but instead likely functions to regulate localization of non-SMC cohesin subunits to chromosomes; in mitotic cells, TIM-1 is present diffusely but most intensely in interphase nuclei and by the metaphase-to-anaphase transition, TIM-1 levels are much reduced and excluded from condensed chromatin; in germ cells, TIM-1 is diffuse in pre-meiotic nuclei, disappears abruptly as nuclei enter meiotic prophase, and then reappears in diplotene/diakinesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22940
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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12.241M12.242M12.243M12.244M12.245M12.246M12.247M12.248M12.249M12.250M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions