Predicted to enable DNA binding activity. Involved in embryo development; regulation of sister chromatid cohesion; and sister chromatid cohesion. Located in nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator).
WB Description
tim-1 encodes the C. elegans ortholog of mammalian timeless and Drosophila timeout proteins; in C. elegans, TIM-1 activity is essential for regulation of chromatid cohesion and thus, for proper meiotic and mitotic chromosome behavior and normal embryonic development; in addition, TIM-1 appears to also play a role in regulation of developmental timing, controlling the temporal identity of hypodermal seam cells during postembryonic development; during meiosis, TIM-1 activity is required for assembly of non-SMC members of the cohesin complex (REC-8 and SCC-3 in meiosis) onto chromosomes; immunoprecipitation experiments demonstrate that TIM-1 associates with mitotic cohesin subunits SMC-1, SMC-3, SCC-1, and SCC-3 in vivo, although TIM-1 is unlikely to be a core member of the cohesin complex but instead likely functions to regulate localization of non-SMC cohesin subunits to chromosomes; in mitotic cells, TIM-1 is present diffusely but most intensely in interphase nuclei and by the metaphase-to-anaphase transition, TIM-1 levels are much reduced and excluded from condensed chromatin; in germ cells, TIM-1 is diffuse in pre-meiotic nuclei, disappears abruptly as nuclei enter meiotic prophase, and then reappears in diplotene/diakinesis.