Gene

svh-1

Species
Caenorhabditis elegans
Symbol
svh-1
Name
Suppressor of VHp-1 deletion lethality 1
Synonyms
  • C07G1.1
  • CELE_C07G1.1
Biotype
protein coding gene
Automated Description
Predicted to enable serine-type endopeptidase activity. Involved in several processes, including positive regulation of gonad development; positive regulation of nematode pharyngeal pumping; and protein destabilization. Predicted to be located in extracellular space. Is expressed in ADLL and ADLR. Human ortholog(s) of this gene implicated in enterokinase deficiency. Orthologous to human TMPRSS15 (transmembrane serine protease 15).
WB Description
svh-1 encodes a homolog of human TRYP1 and ELA2; mutation of human TRYP1 or ELA2 leads, respectively, to hereditary pancreatitis (OMIM:276000) or cyclic haematopoiesis (OMIM:162800).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24258
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.207M8.208M8.209M8.210M8.211M8.212M8.213M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            svh-1 molecule type
            Interactor gene
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              Genetic Interactions

              svh-1 role
              svh-1 genetic perturbation
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