Gene

uba-2

Species
Caenorhabditis elegans
Symbol
uba-2
Name
UBA (human ubiquitin) related 2
Synonyms
  • CELE_W02A11.4
  • W02A11.4
Biotype
protein coding gene
Automated Description
Enables SUMO activating enzyme activity. Involved in several processes, including anterior/posterior pattern specification; nematode larval development; and protein sumoylation. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2).
WB Description
uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10953
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
12.742M12.743M12.744M12.745M12.746M12.747M12.748M12.749M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions