Gene

ubc-9

Species
Caenorhabditis elegans
Symbol
ubc-9
Name
UBiquitin Conjugating enzyme 9
Synonyms
  • CELE_F29B9.6
  • F29B9.6
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; SAM domain binding activity; and SUMO conjugating enzyme activity. Involved in several processes, including chordate pharyngeal muscle development; negative regulation of transcription by RNA polymerase II; and protein sumoylation. Predicted to be located in nuclear envelope. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; coelomocyte; germ line; pharynx; and tail. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I).
WB Description
ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24067
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            4.6512M4.6514M4.6516M4.6518M4.6520M4.6522M4.6524M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ubc-9 molecule type
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              Genetic Interactions

              ubc-9 role
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