Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in ERAD pathway; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in intestine; nervous system; and rectal gland cell. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2).
WB Description
ubc-14 encodes an E2 ubiquitin-conjugating enzyme; by homology, UBC-14 is predicted to function in the covalent attachment of ubiquitin molecules to protein substrates, via its association with an E3 ubiquitin-protein ligase; loss of ubc-14 activity via RNAi results in embryonic lethality at a stage after gastrulation but prior to muscle twitching, and in abnormal larval tail morphology.