Gene

ubc-14

Species
Caenorhabditis elegans
Symbol
ubc-14
Name
UBiquitin Conjugating enzyme 14
Synonyms
  • CELE_Y87G2A.9
  • Y87G2A.9
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in ERAD pathway; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in intestine; nervous system; and rectal gland cell. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2).
WB Description
ubc-14 encodes an E2 ubiquitin-conjugating enzyme; by homology, UBC-14 is predicted to function in the covalent attachment of ubiquitin molecules to protein substrates, via its association with an E3 ubiquitin-protein ligase; loss of ubc-14 activity via RNAi results in embryonic lethality at a stage after gastrulation but prior to muscle twitching, and in abnormal larval tail morphology.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24067
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.5820M13.5825M13.5830M13.5835M13.5840M13.5845M13.5850M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions