Enables ubiquitin conjugating enzyme binding activity. Involved in regulation of locomotion involved in locomotory behavior and regulation of protein localization to cell surface. Located in cytosol; neuron projection; and nucleus. Is expressed in several structures, including anus; distal tip cell; germ line; neurons; and ventral nerve cord. Orthologous to several human genes including UBE2V2 (ubiquitin conjugating enzyme E2 V2).
WB Description
uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; UEV-1 activity is required cell autonomously for normal trafficking of the GLR-1 glutamate receptor and consequently, for normal locomotory behavior; UEV-1 physically interacts with the UBC-13 ubiquitin conjugating enzyme that is also required for normal locomotory behavior and that is also likely involved in the DNA damage response; a uev-1::gfp reporter fusion is expressed in a wide variety of tissues including the pharynx, neurons, muscle cells, vulva, intestine, distal tip cell, and cells in the anus/tail; UEV-1 reporter fusions localize to nuclei, the cytosol, and ventral cord neurites.