Version: 8.0.0
Date: Tue Jan 28 2025
unc-6
Caenorhabditis elegansWB:WBGene00006746
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

unc-6

Species
Caenorhabditis elegans
Symbol
unc-6
Name
UNCoordinated 6
Synonyms
  • CELE_F41C6.1
  • F41C6.1
Biotype
protein coding gene
Automated Description
Predicted to enable signaling receptor binding activity. Involved in several processes, including axon guidance; establishment or maintenance of actin cytoskeleton polarity; and regulation of axon guidance. Acts upstream of or within dendrite morphogenesis. Located in axon; basement membrane; and cytoplasm. Is expressed in several structures, including P1; P10; accessory cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to several human genes including NTN1 (netrin 1).
WB Description
unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates circumferential axon migrations as well as migration of mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; in addition, UNC-6 mediates anchor cell (AC) invasion by regulating localization of the UNC-40 netrin receptor to the invasive plasma membrane of the AC, allowing for subsequent formation of an invasive membrane domain; a secreted molecule, UNC-6 is first expressed during embryogenesis in ventral epidermoblasts; additional expression is seen in neurons and sheath cells; UNC-6 is involved in both attractive and repulsive interactions mediated by the UNC-40 and UNC-5 netrin receptors, respectively.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10574
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          unc-6 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
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            Genetic Interactions

            unc-6 role
            unc-6 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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