Gene

unc-6

Species
Caenorhabditis elegans
Symbol
unc-6
Name
UNCoordinated 6
Synonyms
  • CELE_F41C6.1
  • F41C6.1
Biotype
protein coding gene
Automated Description
Predicted to enable signaling receptor binding activity. Involved in several processes, including axon guidance; establishment or maintenance of actin cytoskeleton polarity; and regulation of axon guidance. Acts upstream of or within dendrite morphogenesis. Located in axon; basement membrane; and cytoplasm. Is expressed in several structures, including P1; P10; accessory cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to several human genes including NTN1 (netrin 1).
WB Description
unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates circumferential axon migrations as well as migration of mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; in addition, UNC-6 mediates anchor cell (AC) invasion by regulating localization of the UNC-40 netrin receptor to the invasive plasma membrane of the AC, allowing for subsequent formation of an invasive membrane domain; a secreted molecule, UNC-6 is first expressed during embryogenesis in ventral epidermoblasts; additional expression is seen in neurons and sheath cells; UNC-6 is involved in both attractive and repulsive interactions mediated by the UNC-40 and UNC-5 netrin receptors, respectively.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10574
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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6.890M6.891M6.892M6.893M6.894M6.895M6.896M6.897M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions