Gene

unc-18

Species
Caenorhabditis elegans
Symbol
unc-18
Name
UNCoordinated 18
Synonyms
  • CELE_F27D9.1
  • F27D9.1
Biotype
protein coding gene
Automated Description
Enables syntaxin binding activity. Involved in chemical synaptic transmission and positive regulation of neurotransmitter secretion. Located in axon. Is expressed in intestine; nervous system; and uv1. Used to study alcohol use disorder and developmental and epileptic encephalopathy. Human ortholog(s) of this gene implicated in West syndrome; developmental and epileptic encephalopathy 4; and familial hemophagocytic lymphohistiocytosis 5. Orthologous to several human genes including STXBP1 (syntaxin binding protein 1).
WB Description
unc-18 encodes the C. elegans ortholog of Saccharomyces cervisiae SEC1 and mammalian Munc18 proteins; UNC-18 function as a chaperone for UNC-64/syntaxin, ensuring its anterograde transport from the endoplasmic reticulum to the plasma membrane; UNC-18 also enables the docking of vesicles to synaptic regions before vesicle priming and fusion, and promotes synaptic vesicle exocytosis; UNC-18 may also inhibit excessive exocytosis; UNC-18 is expressed in ventral cord motor neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11679
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            7.6830M7.6835M7.6840M7.6845M7.6850M7.6855M7.6860M

            Sequence Details

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            Expression

            Primary Sources
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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            unc-18 molecule type
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              Genetic Interactions

              unc-18 role
              unc-18 genetic perturbation
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