Gene

unc-31

Species
Caenorhabditis elegans
Symbol
unc-31
Name
UNCoordinated 31
Synonyms
  • CELE_ZK897.1
  • egl-22
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to carbon dioxide; egg-laying behavior; and signal release. Located in several cellular components, including axon; dense core granule; and neuronal cell body. Is expressed in several structures, including egg-laying apparatus; excretory gland cell; nervous system; postcloacal sensillum; and rectal gland cell. Orthologous to several human genes including CADPS2 (calcium dependent secretion activator 2).
WB Description
unc-31 encodes a pleckstrin homology (PH) domain-containing protein that is the C. elegans ortholog of human CADPS/CAPS (calcium-dependent activator protein for secretion OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand; UNC-31 is not required for synaptic vesicle exocytosis; unc-31::gfp transcriptional reporters are expressed in most, if not all, neurons, vulval muscles, vulval cells, the spermatheca, and secretory cells such as the uterine UV1 cells; UNC-31::GFP translational fusions localize to neuronal cell bodies, axonal projections and to sites of synaptic contact, consistent with other dense-core vesicle proteins.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12166
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            12.774M12.776M12.778M12.780M12.782M12.784M12.786M12.788M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            unc-31 molecule type
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              Genetic Interactions

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