Version: 8.0.0
Date: Tue Jan 28 2025
unc-36
Caenorhabditis elegansWB:WBGene00006772
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

unc-36

Species
Caenorhabditis elegans
Symbol
unc-36
Name
UNCoordinated 36
Synonyms
  • C50C3.9
  • CELE_C50C3.9
Biotype
protein coding gene
Automated Description
Enables calcium channel regulator activity; delayed rectifier potassium channel activity; and voltage-gated calcium channel activity. Involved in several processes, including egg-laying behavior; nematode pharyngeal pumping; and serotonin receptor signaling pathway. Located in endoplasmic reticulum membrane and plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in alimentary muscle; body wall musculature; nervous system; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110 and retinal cone dystrophy 4. Orthologous to several human genes including CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3).
WB Description
unc-36 encodes an alpha2/delta subunit of a voltage-gated calcium channel; unc-36 is required for normal locomotion and proper intracellular trafficking, presynaptic localization and functional maturation of the UNC-2 alpha1 subunit of a C. elegans CaV2 channel in sensory and motor neurons; unc-36 also functions in a calcium-dependent pathway that establishes left-right asymmetry in the nervous system during development; recordings of voltage-dependent calcium currents indicate that UNC-36 regulates voltage dependence, kinetics, and conductance of the EGL-19 alpha1 subunit of the body wall muscle voltage-dependent calcium channel; unc-36 is expressed in muscle cells and motor neurons; an UNC-36::GFP localizes to the endoplasmic reticulum and the plasma membrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10166
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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      Transgenic construct
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          unc-36 molecule type
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            Genetic Interactions

            unc-36 role
            unc-36 genetic perturbation
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