Version: 8.0.0
Date: Tue Jan 28 2025
unc-47
Caenorhabditis elegansWB:WBGene00006783
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

unc-47

Species
Caenorhabditis elegans
Symbol
unc-47
Name
UNCoordinated 47
Synonyms
  • CELE_T20G5.6
  • T20G5.6
Biotype
protein coding gene
Automated Description
Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in gamma-aminobutyric acid transport; glycine transport; and neurotransmitter loading into synaptic vesicle. Located in synaptic vesicle. Is expressed in neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1).
WB Description
unc-47 encodes a novel transmembrane vesicular GABA transporter; UNC-47 and UNC-46, a predicted novel transmembrane protein, are required in GABAergic neurons for all GABA neurotransmission, specifically for loading of GABA into synaptic vesicles, where UNC-47 is localized; UNC-47 is required for the localization of UNC-46, and when overexpressed can rescue unc-46 mutant animals; UNC-47 expression in type D neurons is transcriptionally regulated by the UNC-30 homeodomain protein.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48017
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            unc-47 molecule type
            Interactor gene
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              Genetic Interactions

              unc-47 role
              unc-47 genetic perturbation
              Interactor gene
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