Gene

unc-80

Species
Caenorhabditis elegans
Symbol
unc-80
Name
UNCoordinated 80
Synonyms
  • CELE_F25C8.3
  • F25C8.3
Biotype
protein coding gene
Automated Description
Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Is expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit).
WB Description
unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR31781
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
20.880M20.882M20.884M20.886M20.888M20.890M20.892M20.894M20.896M20.898M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions