Gene

vab-19

Species
Caenorhabditis elegans
Symbol
vab-19
Name
Variable ABnormal morphology 19
Synonyms
  • CELE_T22D2.1
  • T22D2.1
Biotype
protein coding gene
Automated Description
Involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development. Located in cell-cell junction; hemidesmosome; and intermediate filament. Is expressed in hypodermis; marginal cell; uterus; and vulD. Used to study cancer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16; palmoplantar keratoderma and woolly hair; and spastic quadriplegic cerebral palsy 2. Orthologous to several human genes including KANK2 (KN motif and ankyrin repeat domains 2).
WB Description
vab-19 encodes an ankyrin repeat-containing protein that is a member of a conserved family of proteins that includes human Kank, a predicted tumor suppressor; during embryonic morphogenesis, vab-19 activity is essential for epidermal elongation and proper attachment of muscle to the epidermis, specifically the localization of attachment structures to muscle-adjacent regions of epidermal cells and normal epidermal actin organization; a VAB-19::GFP fusion protein is expressed in dorsal and ventral epidermal cells where it organizes into circumferential bands and colocalizes with components of epidermal attachment structures; VAB-19::GFP is also detected in mechanosensory neuronal processes; recruitment of VAB-19 to epidermal attachment structures requires activity of VAB-10/Spectraplakin, while VAB-19 and LET-805/Myotactin are mutually required for localization into circumferential stripes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24168
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            2.444M2.445M2.446M2.447M2.448M2.449M2.450M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            vab-19 molecule type
            Interactor gene
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              Genetic Interactions

              vab-19 role
              vab-19 genetic perturbation
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