Gene

pfd-3

Species
Caenorhabditis elegans
Symbol
pfd-3
Name
PreFolDin (molecular chaperone) 3
Synonyms
  • CELE_T06G6.9
  • T06G6.9
Biotype
protein coding gene
Automated Description
Predicted to enable tubulin binding activity. Predicted to be involved in microtubule-based process and tubulin complex assembly. Located in cytoplasm. Is expressed in body wall musculature; oocyte; pharyngeal muscle cell; and vulval muscle. Orthologous to human VBP1 (VHL binding protein 1).
WB Description
pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12409
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
12.7282M12.7284M12.7286M12.7288M12.7290M12.7292M12.7294M12.7296M12.7298M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions