Predicted to enable tubulin binding activity. Predicted to be involved in microtubule-based process and tubulin complex assembly. Located in cytoplasm. Is expressed in body wall musculature; oocyte; pharyngeal muscle cell; and vulval muscle. Orthologous to human VBP1 (VHL binding protein 1).
WB Description
pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.