Gene

ver-1

Species
Caenorhabditis elegans
Symbol
ver-1
Name
VEGF (vascular endothelial growth factor) Receptor family 1
Synonyms
  • CELE_T17A3.1
  • T17A3.1
Biotype
protein coding gene
Automated Description
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in nematode male tail tip morphogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in intestine and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); pancreatic cancer (multiple); and retinal disease (multiple). Orthologous to several human genes including FLT1 (fms related receptor tyrosine kinase 1); FLT3 (fms related receptor tyrosine kinase 3); and FLT4 (fms related receptor tyrosine kinase 4).
WB Description
ver-1 encodes a receptor tyrosine kinase; VER-1 activity is required for remodeling of glial cells during dauer larval development; ver-1 is expressed in amphid and phasmid sheath glia upon dauer entry and when animals are cultivated at high temperature; ver-1 expression is regulated by the TTX-1 homeodomain and ZTF-16 C2H2 zinc finger transcription factors.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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157k158k159k160k161k162k163k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions