Version: 8.0.0Date: Tue Jan 28 2025
Gene
ver-1
- Species
- Caenorhabditis elegans
- Symbol
- ver-1
- Name
- VEGF (vascular endothelial growth factor) Receptor family 1
- Synonyms
- CELE_T17A3.1
- T17A3.1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in nematode male tail tip morphogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in intestine and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); pancreatic cancer (multiple); and retinal disease (multiple). Orthologous to several human genes including FLT1 (fms related receptor tyrosine kinase 1); FLT3 (fms related receptor tyrosine kinase 3); and FLT4 (fms related receptor tyrosine kinase 4).
- WB Description
- ver-1 encodes a receptor tyrosine kinase; VER-1 activity is required for remodeling of glial cells during dauer larval development; ver-1 is expressed in amphid and phasmid sheath glia upon dauer entry and when animals are cultivated at high temperature; ver-1 expression is regulated by the TTX-1 homeodomain and ZTF-16 C2H2 zinc finger transcription factors.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIII:156824...163542 + (6.72 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.