Gene

vha-7

Species
Caenorhabditis elegans
Symbol
vha-7
Name
Vacuolar H ATPase 7
Synonyms
  • C26H9A.1
  • CELE_C26H9A.1
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase binding activity. Predicted to be involved in vacuolar acidification. Predicted to be located in membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in plasma membrane. Is expressed in gonad; hypodermis; and oocyte. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4).
WB Description
vha-7 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-7 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); vha-7 is expressed in hypodermis and uterus; VHA-7 isdispensable for viability, since vha-7(RNAi) animals develop to normal,healthy adults; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-7 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11629
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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12.641M12.642M12.643M12.644M12.645M12.646M12.647M12.648M12.649M12.650M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions