Version: 8.0.0
Date: Tue Jan 28 2025
vha-10
Caenorhabditis elegansWB:WBGene00006919
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

vha-10

Species
Caenorhabditis elegans
Symbol
vha-10
Name
Vacuolar H ATPase 10
Synonyms
  • CELE_F46F11.5
  • F46F11.5
Biotype
protein coding gene
Automated Description
Predicted to enable ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Involved in positive regulation of programmed cell death and programmed cell death. Predicted to be located in presynapse. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to several human genes including ATP6V1G2 (ATPase H+ transporting V1 subunit G2).
WB Description
vha-10 encodes an ortholog of subunit G of the cytoplasmic (V1) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-10 is requiredfor necrosis, since vha-10(RNAi) suppresses necrotic neurodegenerationand thapsigargin-induced cell death; VHA-10 is a predicted cytosolicstator (stalk) component.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12713
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          vha-10 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            vha-10 role
            vha-10 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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