Gene

vha-11

Species
Caenorhabditis elegans
Symbol
vha-11
Name
Vacuolar H ATPase 11
Synonyms
  • CELE_Y38F2AL.3
  • Y38F2AL.3
Biotype
protein coding gene
Automated Description
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development and ovulation. Predicted to be located in cytoplasm and membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in excretory cell; hypodermis; and intestinal cell. Orthologous to several human genes including ATP6V1C1 (ATPase H+ transporting V1 subunit C1).
WB Description
vha-11 encodes, by alternative splicing, two isoforms of an ortholog ofsubunit C of the cytoplasmic (V1) domain of vacuolarproton-translocating ATPase (V-ATPase); VHA-11 is a predicted cytosolicstator (stalk) component; VHA-11 is found in dot-like structures aroundembryonic nuclei, with diffuse distribution in embryonic cytoplasm; inlater embryos (comma stage onward), VHA-11 is found in gut granules (atype of lysosome, expected to require acidification); VHA-11 ispredominantly expressed in the excretory cell and in intestinal cells inthe adult; VHA-11 is required for ovulation and embryogenesis, sincevha-11(RNAi) animals are sterile with polyploid, unmatured oocytes anddead progeny; VHA-11 is also required for normal formation of gutgranules, since vha-11(RNAi) embryonic intestines fail to stain withacridine orange; glo-1 mutant intestines fail to show punctate VHA-11;vha-11 shares an operon with vha-3; transgenic vha-11 complements anull mutation of its S. cerevisiae ortholog, VMA5.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10137
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            2.308M2.309M2.310M2.311M2.312M2.313M2.314M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

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              Genetic Interactions

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