Version: 8.0.0Date: Tue Jan 28 2025
Gene
vha-11
- Species
- Caenorhabditis elegans
- Symbol
- vha-11
- Name
- Vacuolar H ATPase 11
- Synonyms
- CELE_Y38F2AL.3
- Y38F2AL.3
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development and ovulation. Predicted to be located in cytoplasm and membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in excretory cell; hypodermis; and intestinal cell. Orthologous to several human genes including ATP6V1C1 (ATPase H+ transporting V1 subunit C1).
- WB Description
- vha-11 encodes, by alternative splicing, two isoforms of an ortholog ofsubunit C of the cytoplasmic (V1) domain of vacuolarproton-translocating ATPase (V-ATPase); VHA-11 is a predicted cytosolicstator (stalk) component; VHA-11 is found in dot-like structures aroundembryonic nuclei, with diffuse distribution in embryonic cytoplasm; inlater embryos (comma stage onward), VHA-11 is found in gut granules (atype of lysosome, expected to require acidification); VHA-11 ispredominantly expressed in the excretory cell and in intestinal cells inthe adult; VHA-11 is required for ovulation and embryogenesis, sincevha-11(RNAi) animals are sterile with polyploid, unmatured oocytes anddead progeny; VHA-11 is also required for normal formation of gutgranules, since vha-11(RNAi) embryonic intestines fail to stain withacridine orange; glo-1 mutant intestines fail to show punctate VHA-11;vha-11 shares an operon with vha-3; transgenic vha-11 complements anull mutation of its S. cerevisiae ortholog, VMA5.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10137
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrIV:2307815...2314567 - (6.75 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.