Version: 8.0.0
Date: Tue Jan 28 2025
vig-1
Caenorhabditis elegansWB:WBGene00006924
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

vig-1

Species
Caenorhabditis elegans
Symbol
vig-1
Name
VIG (Drosophila Vasa Intronic Gene) ortholog 1
Synonyms
  • CELE_F56D12.5
  • F56D12.5
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity. Part of RISC complex. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1) and HABP4 (hyaluronan binding protein 4).
WB Description
vig-1 encodes a predicted RNA-binding protein orthologous to Drosophila VIG (Vasa Intronic Gene); vig-1 activity is required for proper function of the let-7 miRNA in vivo and thus, for regulating the transition from late larval to adult cell fates; VIG-1 is a component of the 250 kDa RNA-induced silencing complex (RISC) complex and co-immunoprecipates with both TSN-1, the C. elegans Tudor-SN ortholog, and the let-7 miRNA.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12299
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            1.3212M1.3214M1.3216M1.3218M1.3220M1.3222M1.3224M1.3226M1.3228M1.3230M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            vig-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              vig-1 role
              vig-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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