Gene

vps-34

Species
Caenorhabditis elegans
Symbol
vps-34
Name
related to yeast Vacuolar Protein Sorting factor 34
Synonyms
  • B0025.1
  • CELE_B0025.1
Biotype
protein coding gene
Automated Description
Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including determination of adult lifespan; ecdysis, collagen and cuticulin-based cuticle; and phosphatidylinositol-3-phosphate biosynthetic process. Located in cytoplasm; nuclear outer membrane; and nucleolus. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3).
WB Description
vps-34 encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development; in C. elegans, vps-34 is required for vesicular trafficking, including endocytosis, apoptotic cell clearance, and autophagy.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            6.0285M6.0290M6.0295M6.0300M6.0305M6.0310M6.0315M6.0320M6.0325M6.0330M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            vps-34 molecule type
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              Genetic Interactions

              vps-34 role
              vps-34 genetic perturbation
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