Gene

xbx-1

Species
Caenorhabditis elegans
Symbol
xbx-1
Name
X-BoX promoter element regulated 1
Synonyms
  • CELE_F02D8.3
  • F02D8.3
Biotype
protein coding gene
Automated Description
Predicted to enable dynein heavy chain binding activity. Involved in intraciliary retrograde transport and non-motile cilium assembly. Located in several cellular components, including ciliary base; ciliary transition zone; and cytoskeleton. Is expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1).
WB Description
xbx-1 encodes a dynein light intermediate chain; XBX-1 activity is required for retrograde intraflagellar transport and thus, for proper formation of sensory neuron cilia; an XBX-1::YFP reporter fusion protein is found at the ciliary base and migrating along the ciliary axoneme in both anterograde and retrograde directions.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13236
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
14.9804M14.9806M14.9808M14.9810M14.9812M14.9814M14.9816M14.9818M14.9820M14.9822M14.9824M14.9826M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions