Predicted to enable dynein heavy chain binding activity. Involved in intraciliary retrograde transport and non-motile cilium assembly. Located in several cellular components, including ciliary base; ciliary transition zone; and cytoskeleton. Is expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1).
WB Description
xbx-1 encodes a dynein light intermediate chain; XBX-1 activity is required for retrograde intraflagellar transport and thus, for proper formation of sensory neuron cilia; an XBX-1::YFP reporter fusion protein is found at the ciliary base and migrating along the ciliary axoneme in both anterograde and retrograde directions.