Version: 8.0.0Date: Tue Jan 28 2025
Gene
xpa-1
- Species
- Caenorhabditis elegans
- Symbol
- xpa-1
- Name
- human XPA (Xeroderma pigmentosum comp grp A) related 1
- Synonyms
- CELE_K07G5.2
- K07G5.2
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable damaged DNA binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and response to UV-C. Located in nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor).
- WB Description
- xpa-1 encodes a DNA-binding protein orthologous to human XPA (which when mutated leads to Xeroderma Pigmentosum; OMIM:278700); xpa-1 is required for normal survival and resistance to mutagenesis in response to UV light, the extended lifespan of dauer-like mutants, and fertility; XPA-1 is required in UV-irradiated nondauer larvae to prevent WWP-1-mediated proteolysis of AMA-1; transgenic xpa-1 rescues the UV sensitivity of the null allele xpa-1(mn157); xpa-1 is a core NER (Nuclear Excision Repair) factor (other members being xpf-1, xpg-1, and ercc-1); xpa-1 is essential for the repair of UV-induced DNA lesions and has been demonstrated to be required in both the global genome repair (GGR) and transcription coupled repair (TCR) pathways; following UV irradiation, XPA-1 activity is essential for normal meiotic development, induction of germ cell apoptosis, and the survival of germ cells and somatic tissue (even at relatively low doses of UV irradiation); loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) renders animals hypersensitive to UV light at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10142
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrI:7159714...7160917 + (1.20 kb)
- Assembly version
- WBcel235
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.