Predicted to enable SUMO transferase activity. Involved in embryo development; meiotic chromosome segregation; and synaptonemal complex disassembly. Located in synaptonemal complex. Orthologous to human RNF212B (ring finger protein 212B).
WB Description
zhp-3 encodes a RING finger/coiled-coil protein orthologous to budding yeast Cst9p/Zip3 (meiotically expressed) and human RNF212 (associated with varying recombination rate), RNF212B, and HEI10; ZHP-3 is paralogous to F55A12.10, D1081.9 and Y39B6A.16; ZHP-3 is expressed during meiosis and required for meiotic crossing-over; the protein physically interacts with Y39B6A.16; ZHP-3 and Y39B6A.16 localize throughout the synaptonemal complex during early meiotic prophase, and later accumulate at recombination intermediates designated for crossover formation; together with F55A12.10 and D1081.9, these proteins regulate meiotic recombination; zhp-3 mutations are enhanced by mutations in smo-1, which encodes the C. elegans SUMO ortholog, indicating that SMO-1 also participates in SC disassembly and bivalent formation.