Gene

zhp-3

Species
Caenorhabditis elegans
Symbol
zhp-3
Name
Zip (yeast meiotic zipper) Homologous Protein 3
Synonyms
  • CELE_K02B12.8
  • K02B12.8
Biotype
protein coding gene
Automated Description
Predicted to enable SUMO transferase activity. Involved in embryo development; meiotic chromosome segregation; and synaptonemal complex disassembly. Located in synaptonemal complex. Orthologous to human RNF212B (ring finger protein 212B).
WB Description
zhp-3 encodes a RING finger/coiled-coil protein orthologous to budding yeast Cst9p/Zip3 (meiotically expressed) and human RNF212 (associated with varying recombination rate), RNF212B, and HEI10; ZHP-3 is paralogous to F55A12.10, D1081.9 and Y39B6A.16; ZHP-3 is expressed during meiosis and required for meiotic crossing-over; the protein physically interacts with Y39B6A.16; ZHP-3 and Y39B6A.16 localize throughout the synaptonemal complex during early meiotic prophase, and later accumulate at recombination intermediates designated for crossover formation; together with F55A12.10 and D1081.9, these proteins regulate meiotic recombination; zhp-3 mutations are enhanced by mutations in smo-1, which encodes the C. elegans SUMO ortholog, indicating that SMO-1 also participates in SC disassembly and bivalent formation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22663
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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8.5294M8.5296M8.5298M8.5300M8.5302M8.5304M8.5306M8.5308M8.5310M8.5312M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions