Gene

rbg-3

Species
Caenorhabditis elegans
Symbol
rbg-3
Name
RaB GAP related 3
Synonyms
  • B0393.2
  • CELE_B0393.2
Biotype
protein coding gene
Automated Description
Enables GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Located in cytoplasm. Is expressed in amphid neurons and phasmid neurons. Used to study obesity. Orthologous to human TBC1D5 (TBC1 domain family member 5).
WB Description
rbg-3 encodes a predicted TBC domain-containing RabGTPase-activating protein (RabGAP) similar to the Ypt/Rab specific GTPase-activating protein gyp6; YPT/Rab GTPases and GAPs regulate eukaryotic vesicular transport; RBG-3 functions as a GTPase for both human and elegans RAB-7; rbg-3 interacts with tub-1/Tubby in yeast two-hybrid screens and regulates fat storage along with tub-1, but not life span, suggesting that rbg-3 could function in a endocytic pathway as a target of tub-1 for regulation of fat storage; rbg-3 is expressed in the amphid and phasmid neurons in the head and localizes to the cytoplasm, this is similar to the expression pattern of tub-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22957
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.7545M4.7550M4.7555M4.7560M4.7565M4.7570M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions