Gene

prdh-1

Species
Caenorhabditis elegans
Symbol
prdh-1
Name
PRoline DeHydrogenase homolog 1
Synonyms
  • B0513.5
  • CELE_B0513.5
Biotype
protein coding gene
Automated Description
Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to several human genes including PRODH (proline dehydrogenase 1).
WB Description
Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrion. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in hyperprolinemia type 1 and schizophrenia 4. Is an ortholog of human PRODH (proline dehydrogenase 1).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13914
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPRODH9 of 9YesYes   
Homo sapiensPRODH23 of 9NoYes   
Mus musculusProdh9 of 9YesYes   
Mus musculusProdh23 of 9NoYes   
Rattus norvegicusProdh9 of 9YesYes   
Rattus norvegicusProdh23 of 9NoYes   
Xenopus tropicalisprodh8 of 9YesYes   
Danio rerioprodha9 of 9YesYes   
Danio rerioprodhb6 of 9NoYes   
Danio reriozgc:920403 of 9NoYes   
Drosophila melanogasterslgA9 of 9YesYes   
Saccharomyces cerevisiaePUT16 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.869M13.870M13.871M13.872M13.873M13.874M13.875M13.876M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 7 annotations
prdh-1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
chn-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36027913
protein
daf-15Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:35479415
protein
glh-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:31506335
protein
gras-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36809245
protein
hda-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:34003109
protein
lin-53Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:31397537
protein
sao-1Caenorhabditis elegans
protein
  • affinity chromatography technology
PMID:36323675
Showing 1 - 7 of 7 rows
per page

Genetic Interactions

No data available