Gene

gpx-5

Species
Caenorhabditis elegans
Symbol
gpx-5
Name
Glutathione PeroXidase 5
Synonyms
  • C11E4.1
  • CELE_C11E4.1
Biotype
protein coding gene
Automated Description
Predicted to enable glutathione peroxidase activity. Involved in response to reactive oxygen species. Predicted to be located in extracellular space. Is expressed in head; hypodermis; intestine; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5).
WB Description
gpx-5 encodes a glutathione peroxidase; by homology, GPX-5 is predicted to function to reduce lipid hydroperoxides to their corresponding alcohols and reduce hydrogen peroxide to water to protect cells from damage induced by reactive oxygen species.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11592
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
9.5848M9.5850M9.5852M9.5854M9.5856M9.5858M9.5860M9.5862M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions