Predicted to enable glutathione peroxidase activity. Involved in response to reactive oxygen species. Predicted to be located in extracellular space. Is expressed in head; hypodermis; intestine; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5).
WB Description
gpx-5 encodes a glutathione peroxidase; by homology, GPX-5 is predicted to function to reduce lipid hydroperoxides to their corresponding alcohols and reduce hydrogen peroxide to water to protect cells from damage induced by reactive oxygen species.