Gene

ocrl-1

Species
Caenorhabditis elegans
Symbol
ocrl-1
Name
OCRL (Lowe's oculocerebrorenal syndrome protein) homolog 1
Synonyms
  • C16C2.3
  • CELE_C16C2.3
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and signal transduction. Predicted to be located in early endosome membrane and phagocytic vesicle membrane. Predicted to be active in cytoplasm; membrane; and neuron projection. Human ortholog(s) of this gene implicated in Dent disease 2 and oculocerebrorenal syndrome. Orthologous to several human genes including INPP5B (inositol polyphosphate-5-phosphatase B).
WB Description
The C16C2.3 gene encodes an inositol-1,4,5-triphosphate 5-phosphatase homolog that is homologous to human OCRL.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11200
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.716M9.718M9.720M9.722M9.724M9.726M9.728M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ocrl-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              ocrl-1 role
              ocrl-1 genetic perturbation
              Interactor gene
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