Gene

cysl-1

Species
Caenorhabditis elegans
Symbol
cysl-1
Name
CYsteine Synthase Like 1
Synonyms
  • C17G1.7
  • CELE_C17G1.7
Biotype
protein coding gene
Automated Description
Enables cysteine synthase activity and enzyme binding activity. Involved in cysteine biosynthetic process from serine and response to hypoxia. Located in striated muscle dense body. Is expressed in several structures, including body wall musculature; head ganglion; intestine; neurons; and non-striated muscle.
WB Description
cysl-1 encodes a homolog of sulfhydrylases/cysteine synthases; CYSL-1 functions in neurons to transduce signals from H2S (hydrogen sulfide), which accumulates during hypoxia, to the EGL-9 proline hydroxylase to regulate O2-dependent behavioral plasticity in C. elegans via neuronal activation of the HIF-1 hypoxia-inducible transcription factor.; specifically, CYSL-1 physically interacts with EGL-9 in an H2S-dependent manner to sequester EGL-9 and relieve its inhibitory effect on HIF-1; a CYSL-1::GFP reporter fusion is expressed in the AVM sensory neuron, the BDU interneurons, and the pharyngeal I1 interneurons and M2 motor neurons, as well as in body wall muscles, hypodermis, and intestine; in vitro enzymatic assays and bioinformatics analyses suggest that CYSL-1 does not function as a cysteine synthase in vivo, but instead functions as a signaling molecule to transduce information about the environmental O2 level.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10314
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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9.9526M9.9528M9.9530M9.9532M9.9534M9.9536M9.9538M9.9540M9.9542M9.9544M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions