Gene

stg-1

Species
Caenorhabditis elegans
Symbol
stg-1
Name
STarGazin (mammalian calcium channel) homolog 1
Synonyms
  • C18D1.4
  • CELE_C18D1.4
Biotype
protein coding gene
Automated Description
Enables channel regulator activity. Involved in positive regulation of glutamatergic synaptic transmission. Predicted to be located in membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10; childhood absence epilepsy; and macular degeneration. Orthologous to several human genes including CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2); CACNG3 (calcium voltage-gated channel auxiliary subunit gamma 3); and CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4).
WB Description
stg-1 encodes, along with stg-2, one of two C. elegans TARPs (transmembrane AMPAR regulatory proteins); STG-1 is similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12107
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            10.0565M10.0570M10.0575M10.0580M10.0585M10.0590M10.0595M10.0600M10.0605M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            stg-1 molecule type
            Interactor gene
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              Genetic Interactions

              stg-1 role
              stg-1 genetic perturbation
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